opa3 outer mitochondrial membrane lipid metabolism regulator OPA3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: opa3provided by ZNC
Official Full Name: outer mitochondrial membrane lipid metabolism regulator OPA3provided by ZNC
Primary source: ZFIN:ZDB-GENE-050210-1
See related: Ensembl:ENSDARG00000061761 AllianceGenome:ZFIN:ZDB-GENE-050210-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Acts upstream of or within locomotory behavior; musculoskeletal movement; and regulation of buoyancy. Located in mitochondrion. Is expressed in heart; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 3 and optic atrophy 3. Orthologous to human OPA3 (outer mitochondrial membrane lipid metabolism regulator OPA3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (35838752..35842554, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (35857744..35861546, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mitochondrial OPA3 is required to limit HMG-CoA-derived MGC and protect the electron transport chain against inhibitory compounds in a zebrafish model of Costeff Syndrome
Title: A model of Costeff Syndrome reveals metabolic and protective functions of mitochondrial OPA3.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within musculoskeletal movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of buoyancy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: optic atrophy 3 protein homolog

Names: OPA3 outer mitochondrial membrane lipid metabolism regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.